All of the following are advantages of using single-donor platelets as opposed to random donor platelets, except:

Using single-donor platelets offers several significant advantages over random donor platelets, particularly in terms of patient safety and compatibility. Among these benefits, less antigen exposure, potential HLA matching, and the fact that no pooling is required stand out.

The statement regarding less antigen exposure for patients is important because single-donor platelets are derived from one donor, which minimizes the exposure to multiple donor antigens that can occur with random donor platelets. This is particularly crucial for patients who may have been sensitized to certain antigens after previous transfusions, reducing the risk of transfusion reactions.

HLA matching is another advantage, as single-donor platelets can be selected to match the patient’s HLA type, which is especially beneficial for patients who are platelet refractory. This increases the likelihood that the transfusion will be effective and that the platelets will persist in the recipient's circulation.

Furthermore, when utilizing single-donor platelets, pooling is not necessary since the platelets collected come from one donor, which simplifies the process. Pooling platelets from different donors could potentially increase the risk of transfusion reactions and complicate compatibility issues.

In contrast, the assertion that single-donor platelets require less preparation time can be misleading. The process