For which condition is granulocyte transfusion recommended?

For which condition is granulocyte transfusion recommended?

• A. Severe anemia
• B. Chronic granulomatous disease
• C. Coagulation abnormalities
• D. Aplastic anemia

Answer: (B)

Granulocyte transfusion is most appropriately recommended for patients with chronic granulomatous disease (CGD). This condition is characterized by a defect in the phagocyte's ability to generate reactive oxygen species, which are necessary for killing certain bacteria and fungi. Patients with CGD are particularly susceptible to infectious complications due to their compromised immune response. Granulocyte transfusions provide a source of functional neutrophils, which can enhance the patient's ability to fight infections. These transfusions are typically indicated during severe or recurrent infections in CGD patients, as they may help reduce infection severity and improve outcomes. In contrast, the other conditions listed do not benefit from granulocyte transfusion for their treatment. Severe anemia primarily requires red blood cell transfusions, while coagulation abnormalities are managed with platelet transfusions or clotting factor replacement. Aplastic anemia, characterized by a reduction in hematopoietic stem cells leading to peripheral blood cytopenias, often requires bone marrow transplantation or supportive care rather than granulocyte transfusions.

Granulocyte transfusion is most appropriately recommended for patients with chronic granulomatous disease (CGD). This condition is characterized by a defect in the phagocyte's ability to generate reactive oxygen species, which are necessary for killing certain bacteria and fungi. Patients with CGD are particularly susceptible to infectious complications due to their compromised immune response.

Granulocyte transfusions provide a source of functional neutrophils, which can enhance the patient's ability to fight infections. These transfusions are typically indicated during severe or recurrent infections in CGD patients, as they may help reduce infection severity and improve outcomes.

In contrast, the other conditions listed do not benefit from granulocyte transfusion for their treatment. Severe anemia primarily requires red blood cell transfusions, while coagulation abnormalities are managed with platelet transfusions or clotting factor replacement. Aplastic anemia, characterized by a reduction in hematopoietic stem cells leading to peripheral blood cytopenias, often requires bone marrow transplantation or supportive care rather than granulocyte transfusions.