If a patient has an acquired B antigen, which of the following typing results is most likely?

If a patient has an acquired B antigen, which of the following typing results is most likely?

• A. Anti-A 4+, anti-B-3+, A1 cells neg, B cells neg
• B. Anti-A 3+, anti-B neg, A1 cells neg, B cells neg
• C. Anti-A 4+, anti-B 1+, A1 cells neg, B cells 4+
• D. Anti-A 4+, anti-B 4+, A1 cells 2+, B cells neg

Answer: (C)

The presence of an acquired B antigen in a patient signifies that the individual has developed antibodies against the A antigen while having a B antigen that reacts more weakly than expected. This typically happens in conditions such as intestinal bacteria or other influences that cause an alteration in the antigenic structure of the blood group antigens. In the context of the typing results, an acquired B antigen often leads to a mixed field reaction when testing for the B antigen because the antigen is present but may not react strongly. Therefore, in the scenario presented, option C indicates a strong reaction to the anti-A reagent (4+) and a weaker reaction to the anti-B reagent (1+). Additionally, with acquired B antigen, one would expect the A1 cells to be negative, given that the presence of the acquired B results in a weak or altered expression that does not readily react with the standard A1 cells. The reactivity of B cells at 4+ shows that the B antigen is still present and reacting appropriately, but one might expect that to be less than the maximum typical results due to the compromised expression. Therefore, the unique pattern seen in this option (4+, 1+, neg, and 4+) aligns well with the characteristics of acquired B antigen typing

The presence of an acquired B antigen in a patient signifies that the individual has developed antibodies against the A antigen while having a B antigen that reacts more weakly than expected. This typically happens in conditions such as intestinal bacteria or other influences that cause an alteration in the antigenic structure of the blood group antigens.

In the context of the typing results, an acquired B antigen often leads to a mixed field reaction when testing for the B antigen because the antigen is present but may not react strongly. Therefore, in the scenario presented, option C indicates a strong reaction to the anti-A reagent (4+) and a weaker reaction to the anti-B reagent (1+).

Additionally, with acquired B antigen, one would expect the A1 cells to be negative, given that the presence of the acquired B results in a weak or altered expression that does not readily react with the standard A1 cells. The reactivity of B cells at 4+ shows that the B antigen is still present and reacting appropriately, but one might expect that to be less than the maximum typical results due to the compromised expression. Therefore, the unique pattern seen in this option (4+, 1+, neg, and 4+) aligns well with the characteristics of acquired B antigen typing