If screening cells, major crossmatch, and patient autocontrol are all positive, what could be the reason?

If screening cells, major crossmatch, and patient autocontrol are all positive, what could be the reason?

• A. Specific cold alloantibody
• B. Specific cold autoantibody
• C. Abnormal protein or nonspecific autoantibody
• D. Cold and warm alloantibody mixture

Answer: (C)

When screening cells, the major crossmatch, and the patient autocontrol all yield positive results, it indicates that there is an underlying issue with the patient's antibody profile. The most plausible explanation for this scenario is the presence of an abnormal protein or a nonspecific autoantibody. In this context, the positive autocontrol suggests that there is an antibody present in the patient's serum that is reacting with the patient's own red blood cells, indicating an autoantibody may be involved. An abnormal protein could refer to a condition where there are paraproteins present, such as in multiple myeloma, which can lead to nonspecific reactivity in serological tests. This nonspecific reactivity can also occur with the presence of certain autoantibodies that do not target specific antigens. While other options suggest the presence of specific cold or warm alloantibodies or autoantibodies, they do not encompass the broader implication of abnormal protein or nonspecific reactivity which is effectively explained by choice C. Therefore, considering the scenario of positive reactions across multiple tests, the best explanation is linked to the complexity of abnormal proteins or broader nonspecific autoantibody activity, which can give rise to positive reactions without necessarily identifying a specific targeted antigen.

When screening cells, the major crossmatch, and the patient autocontrol all yield positive results, it indicates that there is an underlying issue with the patient's antibody profile. The most plausible explanation for this scenario is the presence of an abnormal protein or a nonspecific autoantibody.

In this context, the positive autocontrol suggests that there is an antibody present in the patient's serum that is reacting with the patient's own red blood cells, indicating an autoantibody may be involved. An abnormal protein could refer to a condition where there are paraproteins present, such as in multiple myeloma, which can lead to nonspecific reactivity in serological tests. This nonspecific reactivity can also occur with the presence of certain autoantibodies that do not target specific antigens.

While other options suggest the presence of specific cold or warm alloantibodies or autoantibodies, they do not encompass the broader implication of abnormal protein or nonspecific reactivity which is effectively explained by choice C. Therefore, considering the scenario of positive reactions across multiple tests, the best explanation is linked to the complexity of abnormal proteins or broader nonspecific autoantibody activity, which can give rise to positive reactions without necessarily identifying a specific targeted antigen.