In panel results, which antibody specificity is suspected when the pattern indicates something at IAT?

The correct choice indicates that the antibody specificity suspected when the pattern shows something at the Indirect Antiglobulin Test (IAT) is Anti-C and anti-K.

In immunohematology, the IAT is utilized to detect antibodies present in the serum that may react with antigens on the surface of red blood cells. A positive result at this phase suggests the presence of clinically significant antibodies that could cause hemolytic transfusion reactions.

Anti-C is a common IgG antibody that reacts with the C antigen on the Rh blood group system, while anti-K (Kell system) represents another clinically significant antibody. Both of these antibodies can show reactivity at the IAT due to their IgG nature, which typically indicates they are able to cross the placenta and have the potential to cause hemolytic disease of the newborn.

Conversely, the other answer choices involve antibodies that either react less strongly at IAT or are not as clinically consequential. For example, anti-S and anti-E, while they could show reactivity, may not be as commonly suspected when interpreting IAT results since anti-E typically has a weaker reaction. Anti-E and anti-K or anti-Lea and anti-Fyb have similar considerations, as they do not