Select the best donor for a man, blood type AB, in need of a kidney transplant.

Select the best donor for a man, blood type AB, in need of a kidney transplant.

• A. His brother, type AB, HLA matched for class II antigens
• B. His mother, type B, HLA matched for class I antigens
• C. His cousin, type O, HLA matched for major class II antigens
• D. Cadaver donor, type O, HLA matched for some class I and II antigens

Answer: (A)

Choosing the best donor for a kidney transplant involves considering both the blood type compatibility and the human leukocyte antigen (HLA) matching. In this scenario, the man in need of a kidney transplant has blood type AB. Individuals with blood type AB are considered universal recipients for blood transfusions, meaning they can receive blood from any ABO blood group. However, kidney transplantation also requires careful consideration of HLA compatibility, which plays a significant role in the success of the transplant and the potential for rejection. The best donor in this case is his brother, who also has blood type AB and is HLA matched for class II antigens. Since they share the same blood type, there is no concern about ABO incompatibility. The HLA matching further enhances the likelihood of transplant success because matching for class II antigens plays a critical role in the immune response and graft acceptance. In contrast, other potential donors may present issues. The mother, being blood type B, could introduce ABO incompatibility, as AB individuals cannot receive kidneys from B types without an increased risk of rejection. The cousin with type O may not be an ideal choice either; while type O can donate to any blood type, it lacks the specific HLA matching that can be critical for ensuring

Choosing the best donor for a kidney transplant involves considering both the blood type compatibility and the human leukocyte antigen (HLA) matching. In this scenario, the man in need of a kidney transplant has blood type AB.

Individuals with blood type AB are considered universal recipients for blood transfusions, meaning they can receive blood from any ABO blood group. However, kidney transplantation also requires careful consideration of HLA compatibility, which plays a significant role in the success of the transplant and the potential for rejection.

The best donor in this case is his brother, who also has blood type AB and is HLA matched for class II antigens. Since they share the same blood type, there is no concern about ABO incompatibility. The HLA matching further enhances the likelihood of transplant success because matching for class II antigens plays a critical role in the immune response and graft acceptance.

In contrast, other potential donors may present issues. The mother, being blood type B, could introduce ABO incompatibility, as AB individuals cannot receive kidneys from B types without an increased risk of rejection. The cousin with type O may not be an ideal choice either; while type O can donate to any blood type, it lacks the specific HLA matching that can be critical for ensuring