What antibodies could an R1R1 make if exposed to R2R2 blood?

What antibodies could an R1R1 make if exposed to R2R2 blood?

• A. Anti-e and anti-C
• B. Anti-E and anti-c
• C. Anti-E and anti-C
• D. Anti-e and anti-c

Answer: (B)

The correct answer is grounded in the understanding of Rh antigen compatibility and the specific antibodies that can develop in response to exposure to incompatible blood types. An individual with the R1R1 genotype expresses D and C antigens, but does not have e or E antigens, as R1R1 consists of the D and C antigens from the Rh system. When this individual is exposed to R2R2 blood, which contains the E and c antigens, the immune system may recognize these as foreign, as the R1R1 individual does not have those antigens on their red blood cells. Consequently, the individual may produce antibodies against the E antigen and the c antigen to combat the perceived threat. Thus, exposure to R2R2 leads to the potential formation of anti-E and anti-c antibodies, as these are the antigens present in the R2R2 blood type that the R1R1 individual lacks. Understanding this interaction highlights the complexities of blood types and the potential for alloimmunization, especially in transfusion medicine.

The correct answer is grounded in the understanding of Rh antigen compatibility and the specific antibodies that can develop in response to exposure to incompatible blood types. An individual with the R1R1 genotype expresses D and C antigens, but does not have e or E antigens, as R1R1 consists of the D and C antigens from the Rh system.

When this individual is exposed to R2R2 blood, which contains the E and c antigens, the immune system may recognize these as foreign, as the R1R1 individual does not have those antigens on their red blood cells. Consequently, the individual may produce antibodies against the E antigen and the c antigen to combat the perceived threat.

Thus, exposure to R2R2 leads to the potential formation of anti-E and anti-c antibodies, as these are the antigens present in the R2R2 blood type that the R1R1 individual lacks. Understanding this interaction highlights the complexities of blood types and the potential for alloimmunization, especially in transfusion medicine.