What is the crossmatching protocol for platelets and/or plasma?

In the context of crossmatching for platelets and plasma, the protocol generally indicates that no specific testing is required before transfusion. This practice is based on the understanding that the components in platelets and plasma pose a lower risk for hemolytic reactions compared to red blood cells.

When transfusing platelet concentrates or plasma, the primary concerns are ABO compatibility and possible reactions related to antigens other than those found on red blood cells, such as human leukocyte antigens (HLA) or minor blood group antigens, particularly in patients who have had previous transfusions. However, routine crossmatching procedures like those performed for red blood cells are not necessary.

In some specific scenarios, such as when a patient has formed specific antibodies or has a history of transfusion reactions, closer compatibility testing, including HLA matching, may be employed. However, in general, platelets and plasma can be administered without extensive crossmatching procedures, which is why the answer indicating that no testing is required is appropriate.