What is the explainable solution for the presence of anti-M in a patient serum?

What is the explainable solution for the presence of anti-M in a patient serum?

• A. Repeat with 10-minute incubation
• B. Use M-negative A1 cells
• C. Use M-positive A1 cells
• D. No further work is necessary

Answer: (B)

The presence of anti-M in a patient serum indicates that the patient has developed antibodies against the M antigen, which is one of the blood group antigens found on the red blood cell surface. To investigate the significance of these antibodies further, it is essential to use appropriate testing cells that will react in a manner that showcases the presence of this antibody. Using M-negative A1 cells is the correct approach in this case. M-negative red blood cells do not express the M antigen, meaning they will not react with anti-M antibodies. When testing a patient’s serum against these M-negative cells, a negative reaction will occur if anti-M is present, confirming the specificity of the antibody and assisting in determining whether the patient has a fully developed anti-M response that could potentially gel (cause agglutination) against M-positive cells. Furthermore, M-negative A1 cells can effectively serve to confirm the anti-M's reactivity, ensuring the safety of transfusion practices and compatibility testing. The other options would not provide the necessary context or clarity for confirming the presence of anti-M antibodies or could obscure the results. For instance, incubating for 10 minutes or using M-positive A1 cells may not produce a significant result and could lead to confusion if false positives or

The presence of anti-M in a patient serum indicates that the patient has developed antibodies against the M antigen, which is one of the blood group antigens found on the red blood cell surface. To investigate the significance of these antibodies further, it is essential to use appropriate testing cells that will react in a manner that showcases the presence of this antibody.

Using M-negative A1 cells is the correct approach in this case. M-negative red blood cells do not express the M antigen, meaning they will not react with anti-M antibodies. When testing a patient’s serum against these M-negative cells, a negative reaction will occur if anti-M is present, confirming the specificity of the antibody and assisting in determining whether the patient has a fully developed anti-M response that could potentially gel (cause agglutination) against M-positive cells. Furthermore, M-negative A1 cells can effectively serve to confirm the anti-M's reactivity, ensuring the safety of transfusion practices and compatibility testing.

The other options would not provide the necessary context or clarity for confirming the presence of anti-M antibodies or could obscure the results. For instance, incubating for 10 minutes or using M-positive A1 cells may not produce a significant result and could lead to confusion if false positives or