What is the most possible Rh genotype for a patient showing certain Anti-D and Anti-e results?

To determine the most likely Rh genotype for a patient based on certain Anti-D and Anti-e results, it's essential to understand how these antibodies correspond to specific Rh antigen expressions.

In this case, Anti-D is an antibody against the D antigen, which is one of the most critical components of the Rh system. A positive reaction with Anti-D suggests that the patient possesses the D antigen on their red blood cells. On the other hand, the presence of Anti-e typically indicates that the patient lacks the e antigen, which is another Rh antigen.

Among the possible Rh genotypes, the genotype that would most consistently lead to a patient expressing the D antigen (leading to a positive reaction with Anti-D) while potentially lacking the e antigen (resulting in a positive reaction with Anti-e) is R1R1. This genotype expresses the D antigen strongly, confirming the presence of Anti-D reactivity. It is also important to note that R1R1 would only react with Anti-e if the e antigen is absent from the (e–) phenotype, reinforcing that this genotype is possible in the context of Anti-e presence.

In contrast, other genotypes like R1r' or R0r may not fit as neatly into these serological results