What should be done if a noticeable clot is found in an RBC unit?

When a noticeable clot is found in a red blood cell (RBC) unit, the most appropriate action is to not issue the unit. The presence of a clot indicates potential contamination or coagulation issues, which could pose significant risks to the recipient. Transfusing a unit with a clot may introduce foreign material into the patient’s bloodstream and can lead to adverse reactions or transfusion-related complications.

Blood banks have strict quality control measures to ensure that all issued blood products are safe for transfusion. A clot can be a sign that platelets or other coagulation factors have been activated within the unit, which may not be acceptable for any transfusions. Therefore, the safest course of action is to refrain from issuing the unit and to investigate the cause of the clot, ensuring that the integrity and safety of blood products remain uncompromised.