What type of antibody might persist with weak positive reactions for several panel cells?

The persistence of weak positive reactions for several panel cells is characteristic of High titer low avidity (HTLA) antibodies. These antibodies are often detected in blood bank serology and can present with weak reactivity because they have a high titer, meaning there are many antibodies present, but these antibodies bind to their target antigens with low avidity. This low avidity can lead to weakly reactive results on screening tests.

In the context of blood banking and serological testing, HTLA antibodies do not typically have the same strong, consistent reactions as other antibodies, making their presence detectable but often weak in intensity. Their behavior is important in the interpretation of antibody panels, as they may affect the results without indicating the presence of clinically significant antibodies that could cause reactions in transfusion scenarios.

Other options may involve antibodies that either react strongly with specific low- or high-frequency antigens or are related to HLA compatibility, which generally present more robust reactions. However, HTLA antibodies uniquely are understood to create this pattern of weak positivity across multiple panel cells.