What type of blood should be given to an individual with an anti-Leb that reacts 1+ at the IAT phase?

When selecting blood for an individual with anti-Leb that reacts 1+ at the IAT (Indirect Antiglobulin Test) phase, it is crucial to consider the specific antibodies present and their potential impact on transfusion reactions. The individual has developed an antibody against the Leb antigen, which means that their immune system has recognized this antigen as foreign and formed antibodies against it.

Administering blood that is negative for the Leb antigen is the appropriate choice because it minimizes the risk of an immune response. If the transfused blood contains the Leb antigen, the recipient's anti-Leb antibodies could bind to these antigens, leading to hemolysis or other immune-mediated complications. Therefore, selecting blood that is negative for the Leb antigen ensures compatibility and safety for the patient.

While the option of giving blood that is negative for both Lea and Leb antigens could also be considered safe, it is not necessary when the anti-Leb is the sole relevant antibody identified. Administering blood with the Leb antigen would pose a significant risk of a transfusion reaction, and considering the low clinical significance of certain antibodies, such as anti-Lea, does not apply here, as the presence of anti-Leb is indeed clinically significant. Thus, the correct choice