What type of proteins do monoclonal gammopathies predominantly involve?

What type of proteins do monoclonal gammopathies predominantly involve?

• A. IgA antibodies
• B. IgM antibodies
• C. IgG antibodies
• D. All immunoglobulin classes

Answer: (C)

Monoclonal gammopathies predominantly involve IgG antibodies because these conditions are characterized by the overproduction of a single clone of plasma cells, which typically secrete large quantities of a specific immunoglobulin. The most common type of monoclonal gammopathy is multiple myeloma, which most frequently produces IgG. Despite the presence of other immunoglobulin classes, IgG is the primary class associated with these disorders. While some monoclonal gammopathies can involve IgA and IgM as well, they are less common compared to those involving IgG. The term "monoclonal" refers specifically to the uniformity of the antibody produced by a single clone of cells, thus frequently resulting in the predominance of one specific class, most notably IgG in the majority of cases.

Monoclonal gammopathies predominantly involve IgG antibodies because these conditions are characterized by the overproduction of a single clone of plasma cells, which typically secrete large quantities of a specific immunoglobulin. The most common type of monoclonal gammopathy is multiple myeloma, which most frequently produces IgG.

Despite the presence of other immunoglobulin classes, IgG is the primary class associated with these disorders. While some monoclonal gammopathies can involve IgA and IgM as well, they are less common compared to those involving IgG. The term "monoclonal" refers specifically to the uniformity of the antibody produced by a single clone of cells, thus frequently resulting in the predominance of one specific class, most notably IgG in the majority of cases.