When may an IS crossmatch be performed?

When may an IS crossmatch be performed?

• A. When a patient is being massively transfused
• B. When there is no history of antibodies and the current antibody screen is negative
• C. When blood is being emergency released
• D. When a patient has not been transfused in the past 3 months

Answer: (B)

An immediate spin crossmatch (IS crossmatch) is appropriately performed when there is no history of antibodies and the current antibody screen is negative. This scenario suggests that the patient's serum does not contain antibodies that could react with the donor red blood cells (RBCs). By performing an IS crossmatch, blood compatibility can be confirmed quickly, providing safety for the patient without additional complex testing, as the risk of transfusion reactions associated with antibodies is minimal in this context. In situations where patients are massively transfused or require emergency blood release, more comprehensive testing such as a type and screen or a full crossmatch may be advisable due to the potential for underlying antibodies. For patients who have not been transfused in the past three months, the absence of transfusion history does not inherently guarantee that they have no antibodies, which is why the IS crossmatch is not necessarily indicated without the aforementioned conditions being met.

An immediate spin crossmatch (IS crossmatch) is appropriately performed when there is no history of antibodies and the current antibody screen is negative. This scenario suggests that the patient's serum does not contain antibodies that could react with the donor red blood cells (RBCs). By performing an IS crossmatch, blood compatibility can be confirmed quickly, providing safety for the patient without additional complex testing, as the risk of transfusion reactions associated with antibodies is minimal in this context.

In situations where patients are massively transfused or require emergency blood release, more comprehensive testing such as a type and screen or a full crossmatch may be advisable due to the potential for underlying antibodies. For patients who have not been transfused in the past three months, the absence of transfusion history does not inherently guarantee that they have no antibodies, which is why the IS crossmatch is not necessarily indicated without the aforementioned conditions being met.