Which antibody is frequently seen in patients with warm autoimmune hemolytic anemia?

In patients with warm autoimmune hemolytic anemia (AIHA), the antibody that is frequently detected is typically an anti-e antibody. Warm AIHA primarily involves antibodies that react at body temperature, which are often warm-reactive IgG antibodies, and these commonly target specific red blood cell antigens.

The anti-e antibody is an example of such a warm-reactive antibody. This antibody is part of the Rh blood group system and is known to cause hemolysis due to its binding to red blood cells, leading to their premature destruction by macrophages in the spleen. The presence of anti-e can lead to positive serologic tests for antibodies against red blood cells, and it plays a significant role in transfusion management and can be a contributing factor to hemolytic events in these patients.

In contrast, other antibodies listed, such as anti-Jka, anti-K, and anti-Fyb, are not as commonly associated with warm autoimmune hemolytic anemia. While they may be present in other conditions or with certain individuals' immunogenic responses, they do not have the same frequency or established association with warm AIHA as anti-e does. The focus on warm-reactive antibodies, particularly anti-e, helps in understanding the immunological profile of patients