Which antibody is most likely to show a dosage effect during identification?

The antibody that is most likely to show a dosage effect during identification is Anti-Jk.

A dosage effect refers to the phenomenon where the strength or reactivity of an antibody varies depending on the number of corresponding antigens present on the red blood cells. This is particularly significant for antibodies that react with blood group antigens that exhibit codominant inheritance, which means that different alleles can both contribute to the expression of antigens on the cell surface.

Anti-Jk is an antibody directed against the JK antigen system, which includes Jka and Jkb antigens. This system is inherited as two codominant alleles. Therefore, individuals who are homozygous for a particular antigen (e.g., Jka/Jka) will express more of that antigen than those who are heterozygous (e.g., Jka/Jkb). Consequently, the reactivity of Anti-Jk antibodies can vary based on the specificity to the antigens present, leading to a measurable dosage effect wherein the intensity of hemolysis or agglutination will be greater with homozygous cells compared to heterozygous cells.

In contrast, while other antibodies such as Anti-M, Anti-K, and Anti-I may have certain characteristics in blood grouping