Which antibody was detected in a pregnant woman that causes fetal distress and reacts at the IAT phase?

The detection of the antibody that causes fetal distress and reacts at the Indirect Antiglobulin Test (IAT) phase is associated with Anti-Lub.

Anti-Lub is an antibody targeting the Lutheran blood group antigen, specifically the Lub antigen. This antibody is known to be capable of crossing the placenta, potentially leading to hemolytic disease of the newborn (HDN) if the fetus expresses the Lub antigen. In pregnant women, the presence of such an antibody can result in complications that manifest as fetal distress due to the destruction of fetal red blood cells, hence leading to anemia, jaundice, or more severe clinical outcomes.

The significance of reacting at the IAT phase is that it indicates the antibody is not likely to cause immediate hemolysis but rather sensitizes red blood cells, leading to possible complications during pregnancy. The ability to recognize and manage the presence of Anti-Lub is crucial in prenatal care to minimize risks to the fetus.

Other antibodies such as Anti-Lea, Anti-Lua, and Anti-Xga are less frequently associated with significant fetal distress or hemolytic disease in pregnancy. Specifically, Anti-Lea and Anti-Lua are often clinically insignificant compared to Anti-Lub, and although Anti-Xga can react with red