Which antibody would not be detected by group O screening cells?

Which antibody would not be detected by group O screening cells?

• A. Anti-N
• B. Anti-A1
• C. Anti-Dia
• D. Anti-k

Answer: (B)

The reason why Anti-A1 would not be detected by group O screening cells is that group O screening cells lack A antigens on their surface. Anti-A1 specifically targets the A1 antigen, which is found on type A and AB red blood cells. Since group O cells do not possess A antigens, any Anti-A1 antibodies present in a sample would not react with them, making it impossible to detect this specific antibody using group O screening cells. In contrast, the other antibodies listed—Anti-N, Anti-Dia, and Anti-k—would have the potential for detection if the corresponding antigens were present on other screening cells, but group O cells are unlikely to interact with Anti-A1 specifically due to the absence of A antigens. This characteristic restricts the detection capability for antibodies like Anti-A1 in the context of screening with group O cells.

The reason why Anti-A1 would not be detected by group O screening cells is that group O screening cells lack A antigens on their surface. Anti-A1 specifically targets the A1 antigen, which is found on type A and AB red blood cells. Since group O cells do not possess A antigens, any Anti-A1 antibodies present in a sample would not react with them, making it impossible to detect this specific antibody using group O screening cells.

In contrast, the other antibodies listed—Anti-N, Anti-Dia, and Anti-k—would have the potential for detection if the corresponding antigens were present on other screening cells, but group O cells are unlikely to interact with Anti-A1 specifically due to the absence of A antigens. This characteristic restricts the detection capability for antibodies like Anti-A1 in the context of screening with group O cells.