Which CD marker is present during the first stage of T cell development?

Which CD marker is present during the first stage of T cell development?

• A. CD 1
• B. CD 2
• C. CD 3
• D. CD 4 or CD 8

Answer: (B)

The presence of CD2 as a marker during the first stage of T cell development is significant because CD2 is an important adhesion molecule that is expressed on all T cells as they begin their maturation process. During the early stages of T cell development, particularly in the thymus, precursor T cells—known as thymocytes—start to express CD2 which facilitates their interaction with other cells and is crucial for their development and differentiation. In the context of thymocyte development, CD2 plays a role in signaling pathways that promote thymocyte survival and proliferation, thereby facilitating further maturation events leading to the later stages when other markers, such as CD3, CD4, and CD8, come into play. While other markers appear at various stages of T cell development, CD2's involvement in the very early phases sets the stage for subsequent maturation and differentiation processes important for the adaptive immune response.

The presence of CD2 as a marker during the first stage of T cell development is significant because CD2 is an important adhesion molecule that is expressed on all T cells as they begin their maturation process. During the early stages of T cell development, particularly in the thymus, precursor T cells—known as thymocytes—start to express CD2 which facilitates their interaction with other cells and is crucial for their development and differentiation.

In the context of thymocyte development, CD2 plays a role in signaling pathways that promote thymocyte survival and proliferation, thereby facilitating further maturation events leading to the later stages when other markers, such as CD3, CD4, and CD8, come into play. While other markers appear at various stages of T cell development, CD2's involvement in the very early phases sets the stage for subsequent maturation and differentiation processes important for the adaptive immune response.