Which condition is characterized by an IgM spike on an electrophoretic pattern?

Waldenström's macroglobulinemia is characterized by an increase in immunoglobulin M (IgM) levels, which manifests as an IgM spike on an electrophoretic pattern. This condition is a type of lymphoproliferative disorder, specifically a form of non-Hodgkin lymphoma, originating from a proliferation of IgM-secreting B lymphocytes.

The presence of the IgM spike is a key diagnostic feature and is indicative of the underlying Malignant proliferation of these B cells. Patients may present with symptoms such as hyperviscosity syndrome due to the elevated levels of IgM, leading to complications like bleeding, visual disturbances, and neurological symptoms.

In contrast, hypogammaglobulinemia involves a decrease in immunoglobulin levels overall, failing to show an IgM spike. Multicystic kidney disease does not directly relate to immunoglobulin levels but instead refers to a congenital condition of the kidneys. Wiskott-Aldrich syndrome, characterized by immunodeficiency, eczema, and thrombocytopenia, also would not present with an IgM spike on an electrophoretic pattern, as it is associated with a deficiency of antibody production. Thus, Waldenström's macroglob