Which donor unit is appropriate for a recipient with anti-c antibodies?

Which donor unit is appropriate for a recipient with anti-c antibodies?

• A. r ́r
• B. R0R1
• C. R2r ́
• D. r ́ry

Answer: (D)

When considering a recipient with anti-c antibodies, it is essential to choose a donor unit compatible with their immune response. The recipient's formation of anti-c antibodies indicates that they have likely been sensitized to the c antigen, which is present on red blood cells. Therefore, it is crucial to select a donor unit that lacks the c antigen to prevent hemolytic reactions. In this context, the appropriate choice would be a donor unit that presents the phenotype without the c antigen. The phenotype represented by the choice includes the r ́r configuration, which lacks the c antigen and is compatible with the recipient's antibodies. This selection entails that the donor unit can exist in various configurations, ensuring the best match and safety for the patient. Donor units with the other phenotypes, such as R0R1, R2r ́, or r ́r, may include the c antigen and thus would not be appropriate for a recipient with anti-c antibodies, which could provoke a significant immune response and potentially cause transfusion reactions. Therefore, choosing a unit without the c antigen is crucial for ensuring the recipient's safety and compatibility during blood transfusion.

When considering a recipient with anti-c antibodies, it is essential to choose a donor unit compatible with their immune response. The recipient's formation of anti-c antibodies indicates that they have likely been sensitized to the c antigen, which is present on red blood cells. Therefore, it is crucial to select a donor unit that lacks the c antigen to prevent hemolytic reactions.

In this context, the appropriate choice would be a donor unit that presents the phenotype without the c antigen. The phenotype represented by the choice includes the r ́r configuration, which lacks the c antigen and is compatible with the recipient's antibodies. This selection entails that the donor unit can exist in various configurations, ensuring the best match and safety for the patient.

Donor units with the other phenotypes, such as R0R1, R2r ́, or r ́r, may include the c antigen and thus would not be appropriate for a recipient with anti-c antibodies, which could provoke a significant immune response and potentially cause transfusion reactions. Therefore, choosing a unit without the c antigen is crucial for ensuring the recipient's safety and compatibility during blood transfusion.