Which hepatitis antibody confers immunity against reinfection with hepatitis B virus?

The presence of Anti-HBs (antibodies against hepatitis B surface antigen) is significant because it indicates that a person has either recovered from a hepatitis B infection or has been successfully vaccinated against the virus. This antibody plays a vital role in conferring immunity against reinfection with hepatitis B virus.

When a person is exposed to hepatitis B virus, their immune system responds by producing antibodies, including Anti-HBs. The detection of Anti-HBs in the blood signifies that the individual has a protective level of antibodies, thus being immune to future infections. This is particularly important for both individual health and public health strategies aimed at controlling the spread of hepatitis B.

Other antibodies like Anti-HBc IgM and Anti-HBc IgG represent different aspects of hepatitis B infection. Anti-HBc IgM signifies acute infection, while Anti-HBc IgG indicates past infection. Anti-HBe is related to viral replication but does not directly confer immunity. In contrast, Anti-HBs specifically serves to signal immunity, making it the correct answer to the question.