Which of the following is used in rapid slide tests for the detection of rheumatoid factors?

Which of the following is used in rapid slide tests for the detection of rheumatoid factors?

• A. Whole IgM molecules
• B. Fc portion of the IgG molecule
• C. Fab portion of the IgG molecule
• D. Fc portion of the IgM molecule

Answer: (B)

The detection of rheumatoid factors (RF) in rapid slide tests typically relies on the interaction of RF with the Fc portion of immunoglobulin G (IgG). Rheumatoid factors are autoantibodies that primarily target the Fc region of IgG molecules, recognizing and binding to this specific structural area. When conducting a rapid slide test for rheumatoid factors, the profile of the assay is designed to capture these interactions effectively. The Fc portion of IgG serves as the ideal target because it is the part of the molecule that binds to the rheumatoid factor, allowing for the formation of immune complexes that can be visualized in the test. This interaction is fundamental to the utility of the test, as the presence of rheumatoid factors signifies an autoimmune response typical of rheumatoid arthritis. The other options, while components of immunoglobulin molecules, do not play a role in this specific assay. Whole IgM molecules and the Fab portion of IgG do not specifically interact with rheumatoid factors in the way that the Fc portion of IgG does. The Fc portion of IgM, while it is part of the IgM structure, is less relevant to the detection of RF compared to IgG’s Fc portion, which is why the latter is the correct choice in the context of

The detection of rheumatoid factors (RF) in rapid slide tests typically relies on the interaction of RF with the Fc portion of immunoglobulin G (IgG). Rheumatoid factors are autoantibodies that primarily target the Fc region of IgG molecules, recognizing and binding to this specific structural area.

When conducting a rapid slide test for rheumatoid factors, the profile of the assay is designed to capture these interactions effectively. The Fc portion of IgG serves as the ideal target because it is the part of the molecule that binds to the rheumatoid factor, allowing for the formation of immune complexes that can be visualized in the test. This interaction is fundamental to the utility of the test, as the presence of rheumatoid factors signifies an autoimmune response typical of rheumatoid arthritis.

The other options, while components of immunoglobulin molecules, do not play a role in this specific assay. Whole IgM molecules and the Fab portion of IgG do not specifically interact with rheumatoid factors in the way that the Fc portion of IgG does. The Fc portion of IgM, while it is part of the IgM structure, is less relevant to the detection of RF compared to IgG’s Fc portion, which is why the latter is the correct choice in the context of