Which of the following is true regarding granulocyte concentrates?

Granulocyte concentrates are specialized blood products derived from the donation of white blood cells, particularly neutrophils, and are often used for patients with severe neutropenia or those who need support in fighting infections.

The requirement for crossmatching granulocyte concentrates is essential in practice because these products, like other blood components, can provoke immune reactions in the recipient. Crossmatching helps to ensure compatibility between the donor's and recipient's blood types, minimizing the risk of hemolytic transfusion reactions, which can be particularly severe due to the immunological properties of granulocytes.

While other statements regarding granulocyte concentrates may pertain to parameters such as cell counts, pH, or irradiation, they do not correctly address the necessary considerations for ensuring patient safety and product suitability like crossmatching does. For instance, the maximum granulocyte count or specific pH levels are not universally standardized across facilities for these products, and not all granulocyte transfusions require irradiation, especially if the risk of transfusion-related graft-versus-host disease (TA-GvHD) is low. Thus, crossmatching stands out as a critical process for ensuring the safety and compatibility of granulocyte transfusions.