Which of the following statements regarding FFP is incorrect?

Which of the following statements regarding FFP is incorrect?

• A. FFP must be prepared within 24 hours of collection
• B. After thawing, FFP must be transfused within 24 hours
• C. Storage temperature for FFP with a 1-year shelf life is ≤−18°C
• D. When thawed, FFP must be stored between 1°C-6°C

Answer: (A)

The statement about FFP (Fresh Frozen Plasma) that indicates it must be prepared within 24 hours of collection is incorrect. In reality, FFP can be prepared from whole blood or apheresis plasma and should be frozen as soon as possible, ideally within 6 hours of collection, to preserve clotting factors and other components. After the plasma is separated and frozen properly, it can be stored for up to a year at the recommended temperature of ≤−18°C, which aligns with the options regarding storage temperature and shelf life. The thawing process is critical; once FFP is thawed, it must be transfused within 24 hours, as the stability of clotting factors decreases after thawing. Additionally, once thawed, FFP must be stored between 1°C-6°C to maintain its integrity up until the time of transfusion. This understanding of FFP preparation, storage, and handling is crucial for its effective and safe use in transfusion medicine.

The statement about FFP (Fresh Frozen Plasma) that indicates it must be prepared within 24 hours of collection is incorrect. In reality, FFP can be prepared from whole blood or apheresis plasma and should be frozen as soon as possible, ideally within 6 hours of collection, to preserve clotting factors and other components.

After the plasma is separated and frozen properly, it can be stored for up to a year at the recommended temperature of ≤−18°C, which aligns with the options regarding storage temperature and shelf life. The thawing process is critical; once FFP is thawed, it must be transfused within 24 hours, as the stability of clotting factors decreases after thawing. Additionally, once thawed, FFP must be stored between 1°C-6°C to maintain its integrity up until the time of transfusion.

This understanding of FFP preparation, storage, and handling is crucial for its effective and safe use in transfusion medicine.