Which phenotype do T regulator cells, responsible for controlling autoimmune antibody production, express?

Which phenotype do T regulator cells, responsible for controlling autoimmune antibody production, express?

• A. CD3, CD4, CD8
• B. CD3, CD8, CD25
• C. CD3, CD4, CD25
• D. CD8, CD25, CD56

Answer: (C)

T regulatory cells, often referred to as Tregs, play a crucial role in maintaining immune tolerance and preventing autoimmune responses by regulating the activity of other immune cells. The phenotype of T regulatory cells is characterized by the expression of specific surface markers that distinguish them from other types of T cells. The presence of CD3 is common among all T cells, serving as a coreceptor in T cell activation. However, the defining markers that are particularly important for identifying Tregs include CD4 and CD25. CD4+ Tregs specifically are known for their immunosuppressive functions and capability to modulate the immune response. CD25, which is the alpha chain of the IL-2 receptor, is also a critical marker for Tregs, indicating that these cells can respond to interleukin-2, a key cytokine involved in T cell proliferation and survival. The combination of CD4 and CD25 on Tregs is key to their function in controlling autoimmune antibody production. CD8 is typically associated with cytotoxic T cells rather than regulatory roles, and other combinations present in the options do not include the quintessential Treg markers. Therefore, the phenotype characterized by the expression of CD3, CD4, and CD25 accurately reflects T regulatory cells and their

T regulatory cells, often referred to as Tregs, play a crucial role in maintaining immune tolerance and preventing autoimmune responses by regulating the activity of other immune cells. The phenotype of T regulatory cells is characterized by the expression of specific surface markers that distinguish them from other types of T cells.

The presence of CD3 is common among all T cells, serving as a coreceptor in T cell activation. However, the defining markers that are particularly important for identifying Tregs include CD4 and CD25. CD4+ Tregs specifically are known for their immunosuppressive functions and capability to modulate the immune response. CD25, which is the alpha chain of the IL-2 receptor, is also a critical marker for Tregs, indicating that these cells can respond to interleukin-2, a key cytokine involved in T cell proliferation and survival.

The combination of CD4 and CD25 on Tregs is key to their function in controlling autoimmune antibody production. CD8 is typically associated with cytotoxic T cells rather than regulatory roles, and other combinations present in the options do not include the quintessential Treg markers. Therefore, the phenotype characterized by the expression of CD3, CD4, and CD25 accurately reflects T regulatory cells and their